TNF-α and IL-10 levels in hipoxic ischemic rat brain receiving stem cell

To investigate the effect of intracerebral adipose neural stem cell transplantation in inflammatory process after brain HI. The study used 16male Wistar rats aged 2 months which were randomly divided into following group: Ischemia-Reperfusion group (IR, n=8) and ANSC-treated (IR+ANSC, n=8). IR was performed by right common carotid artery occlusion for hours, hypoxia procedure 1 hour reperfusion. ANSC prepared from tissue processed Laboratory. inserted intracerebally 48 hours blood sample analyzed using ELISA. T-test independent samples statistial analysis. There no significant differences TNF-α level between IR+ANSC group. statistically difference IL-10 groups (P< 0.05). Intracerebral cannot reduce expression increase ischemia induced CCA ligation hypoxia.